Periodic paralysis episodes may result in progressive permanent muscle weakness

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PERMANENT MUSCLE WEAKNESS
(PMW) OCCURS IN A MAJORITY OF
PATIENTS WITH PRIMARY PERIODIC
PARALYSIS (PPP) AND IS OFTEN
IRREVERSIBLE¹

PPP presents as recurrent episodes of temporary paralysis and muscle weakness²

Permanent Muscle Weakness may occur in patients with PPP, a neuromuscular disorder characterized by recurrent episodes of paralysis and muscle weakness.^1-4

Permanent Muscle Weakness may result
in decreased mobility, loss of function, and
reduced participation in social activities.^1,3

Permanent Muscle Weakness can
be incapacitating¹

After years of paralytic episodes, PMW may be irreversible as muscle atrophies. The less common edematous form of PMW may be reversible with treatment.^1-3

Recognize the characteristics of PPP
for earlier diagnosis and management.
Learn more

Contact your Area Business Specialist
[First, Last - ABS@strongbridgebio.com]
to schedule a peer-to-peer discussion
with an expert.

References: 1. Cavel-Greant D, Lehmann-Horn F, Jurkat-Rott K. The impact of permanent muscle weakness on quality of life in periodic paralysis: a survey of 66 patients. Acta Myol. 2012;31:126-133. 2. Cannon SC. Channelopathies of skeletal muscle excitability. Compr Physiol. 2015;5(2):761-790. 3. Charles G, Zheng C, Lehmann-Horn F, Jurkatt-Rott K, Levitt J. Characterization of hyperkalemic periodic paralysis: a survey of genetically diagnosed individuals. J Neurol. 2013;260:2606-2613. 4. Venance SL, Cannon SC, Fialho D, et al. The primary periodic paralyses: diagnosis, pathogenesis and treatment. Brain. 2006;129:8-17.

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KEV-0397 07/2018