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Prescribing Information | Important Safety Information

What is KEVEYIS?

KEVEYIS (pronounced keh-VAY-iss) (dichlorphenamide) is a prescription drug used to treat primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and other similar diseases.

Everyone’s treatment goals and responses to medication are different. Your dose of KEVEYIS can be changed based on your response to KEVEYIS.¹ Work with your doctor to find the right dose to manage both your PPP and any potential side effects.

As with any medication,
you may experience side effects

In clinical studies, some patients treated with KEVEYIS experienced side effects.¹ Talk with your doctor if you are struggling to manage any of these side effects:

	Tingling in your hands or feet
	Trouble thinking or "brain fog"
	A bad taste in your mouth
	Fatigue
	Increased risk of falls
	Any other troublesome side effects

Still having PPP symptoms? This may help

If you continue to experience episodes of muscle weakness or paralysis, ask your doctor if your dose of KEVEYIS should be changed.¹ Sometimes, increasing your dose may help to decrease the number, severity, and length of your episodes.¹

Try not to miss a dose, but if you do…

Don’t worry, it happens to the best of us. Just make sure to take your next dose as scheduled, but do not take more than the prescribed amount.

Remember that taking KEVEYIS as prescribed by your doctor helps you get the full benefit of the medication. Skipping doses means it may not be as effective for you. Here are some tips to help you remember:

	Set daily calendar notifications on your phone
	Develop a routine so taking your medicine becomes second nature
	Ask friends and family to remind you

Need help tracking your PPP?

to track your triggers and episodes

Important Safety Information

What should you tell your healthcare provider before taking KEVEYIS?

Tell your doctor if you are allergic to dichlorphenamide or other sulfa drugs; if you take high doses of aspirin, or if you have lung or liver disease; if you are pregnant, plan to become pregnant, or are breastfeeding or plan to breastfeed.

What should you know about KEVEYIS?

•	Severe allergic and other reactions have happened with sulfonamides (drugs such as KEVEYIS) and have sometimes been fatal. Stop taking KEVEYIS at the first sign of skin rash, swelling, difficulty breathing, or any other unexpected side effect or reaction, and call 911 right away.
•	Tell your healthcare provider if you take aspirin or if another healthcare provider instructs you to begin taking aspirin. High doses of aspirin should not be taken with KEVEYIS.
•	KEVEYIS can cause your body to lose potassium, which can lead to heart problems. Your healthcare provider will measure the potassium levels in your blood before you start treatment and at certain times during treatment.
•	Tell your healthcare provider about all other prescription and over-the-counter medicines you take, including supplements, as some medicines can interact with KEVEYIS.
•	While taking KEVEYIS, your body may produce too much acid or may not be able to remove acid from the body. Your healthcare provider may run tests on a regular basis to check for signs of acid buildup.
•	KEVEYIS may increase your risk of falling. Tell your healthcare provider right away if you experience a fall while taking KEVEYIS.
•	The risks of falls and acid buildup are greater in elderly patients.
•	It is not known whether KEVEYIS is safe or effective for people younger than 18 years of age.

What are the most common side effects with KEVEYIS?

The most common side effects are a feeling of numbness, tingling or burning (“pins and needles”) in the toes, feet, hands or fingers; trouble with memory or thinking; feeling confused; and unpleasant taste in the mouth.

These are not all of the possible side effects of KEVEYIS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call
1-800-FDA-1088.

Please see Full Prescribing Information.

Reference: 1. KEVEYIS (dichlorphenamide) [package insert]. Trevose, PA: Strongbridge Biopharma; 2017.

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STRONGBRIDGE BIOPHARMA^® is a registered trademark of the Strongbridge Biopharma plc. companies,
which include Strongbridge Dublin Limited and Strongbridge U.S. Inc.
KEVEYIS^® is a registered trademark licensed exclusively in the U.S. to Strongbridge Biopharma plc.

KEV-0736 9/2019