Adjusting to your new treatment? Here’s some helpful advice.
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What is Orenitram?
Orenitram (treprostinil) is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram may improve your ability to exercise. It is not known if Orenitram is safe and effective in children under 18 years of age.
IMPORTANT SAFETY INFORMATION  |  FULL PRESCRIBING INFORMATION  |  PATIENT INFORMATION
SETTING EXPECTATIONS
WITH ORENITRAM
During the first few weeks of your treatment, your doctor will adjust the amount of Orenitram you take to find the right dose for you. Orenitram is started at a lower dose and gradually increased as your body gets used to the dose. Keep in mind that side effects may occur as your doctor tries to find the right dose for you. Tell your doctor about any side effects while taking Orenitram. Fortunately, your healthcare team is there to help you.
IMPORTANT ORENITRAM
TIPS TO REMEMBER
Your doctor is here to help
Ask your doctor what you can do to prepare for side effects when they occur. It may also help to keep a journal and track your daily treatment so you can easily share information with your healthcare team.
The most common side effects with treatment are headache, nausea, diarrhea, and flushing (red skin that is warm to the touch). These are not all of the side effects of Orenitram, though. Tell your doctor about any side effects that bother you, get worse over time, or do not go away. The important thing to remember is to stick with your treatment plan—and don’t hesitate to ask your doctor to help with any problems you may be having.
Orenitram treatment tips
There are many ways to keep your treatment schedule top of mind.
Set an alarm to remind you that it’s time for your next dose
Keep a diary to remember which food combinations worked well with your treatment
Plan your treatment around meals and snacks
Keep your Orenitram handy, even when you leave the house
Swallow Orenitram tablets whole, and do not split, chew, or crush them
IMPORTANT SAFETY INFORMATION
Do not take Orenitram if you have severe liver problems.
Before you take Orenitram, tell your healthcare provider if you:
  • Have liver problems, diverticulosis, or any other medical conditions
  • Are pregnant, breastfeeding, and/or plan to become pregnant or breastfeed. It is not known if Orenitram will harm your unborn baby or if Orenitram passes into your breast milk. You and your healthcare provider should decide if you will take Orenitram or breastfeed. You should not do both
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start or stop any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains the same ingredient, treprostinil. Know the medicines you take. Keep a list of them and the dose you take to show to your healthcare provider and pharmacist when you get a new medicine.
Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider. Stopping Orenitram suddenly may cause worsening of your PAH symptoms. If you miss two or more doses of Orenitram, call your healthcare provider. If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.
If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. Take Orenitram with food.
Orenitram can cause serious side effects, including an increased risk of bleeding. This risk could be increased if you are taking blood thinners such as warfarin.
The most common side effects of Orenitram include headache, diarrhea, nausea and flushing. These are not all of the possible side effects of Orenitram. Tell your doctor about any side effects that bother you, get worse over time, or do not go away.
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You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.
Please see Full Prescribing Information and Patient Information.
For additional information about Orenitram, visit www.orenitram.com or call 1-877-UNITHER (1-877-864-8437).
This information is provided for an informational purpose and is not intended as treatment advice. Patients should consult a healthcare professional for treatment advice.
Orenitram is a registered trademark of United Therapeutics Corporation.
© 2018 United Therapeutics Corporation. All rights reserved. US/ORE/0233
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