Follow-up From My Recent Visit

Dear [Preferred Customer Name]:

Email Opener A

Thank you for taking timeout of your busy day to speak with me about RAYOS^® (prednisone) delayed—release tablets. RAYOS is approved for use in variety of conditions, including rheumatoid arthritis, lupus(SLE), acute gouty arthritis, and polymyalgia rheumatica. You can consider delayed—release RAYOS for any patient for whom you would usually consider generic prednisone.

Email Opener B

Thank you again for meeting with me. I enjoyed talking with you about RAYOS^® (prednisone) delayed—release tablets. RAYOS is approved for use in a variety of conditions, including rheumatoid arthritis, lupus (SLE), acute gouty arthritis and polymyalgia rheumatica. You can consider delayed—release RAYOS for any patient for whom you would usually consider generic prednisone.

Email Opener C

I'm sorry we did not have a chance to talk when I stopped by. I wanted to take this opportunity to share some information with you about RAYOS^® (prednisone) delayed—release tablets. RAYOS is approved for use in a variety of conditions, including rheumatoid arthritis, lupus (SLE), acute gouty arthritis, and polymyalgia rheumatica. You can consider delayed—release RAYOS for any patient for whom you would usually consider generic prednisone.

Please refer to the Important Safety Information provided below.

Setup A reinforce

Because some of your patients may benefit from a delayed—release corticosteroid, I wanted to reinforce the following information:

Setup B additional

Because there were a few points we did not get to discuss, I wanted to share the following with you:

Setup C answer to question

You had asked me a question that I wanted to follow up on. Please review the following information and let me know if it provides the answers you need:

Setup D what they missed

Since we did not get a chance to review this information in person, here are some key highlights you may want to consider:

Click here for an

OVERVIEW OF RAYOS.

Click here for an overview of RAYOS.

Get more information on

IDENTIFYING APPROPRIATE

PATIENTS for RAYOS.

Get more information on identifying appropriate patients for RAYOS.

Learn about

FLEXIBLE DOSING AND

AFFORDABLE ACCESS for RAYOS.

Learn about flexible dosing and affordable access for RAYOS.

Learn how

RAYOS DELIVERS TIMED DOSING

That Lasts All Day.

Learn how RAYOS delivers timed dosing that lasts all day.

Find out how

BEDTIME DOSING OF RAYOS COINCIDES

WITH THE RISE OF INFLAMMATION.

Find out how bedtime dosing of RAYOS coincides with the rise of inflammation.

Get resources for

YOUR PATIENTS on RAYOS

Get resources for your patients on RAYOS.

Please refer to the Important Safety Information provided below.

Conclusion A - Try

I hope you will consider prescribing RAYOS for approved indications in your next prednisone patient who could benefit from a delayed—release corticosteroid.

Conclusion B - Continue

I hope you will continue using RAYOS for your patients with certain rheumatic conditions (as specified in the Prescribing Information) in the future.

Conclusion C - Expand

I hope that you will consider expanding your use of RAYOS to include patients with certain other rheumatic conditions (as specified in the Prescribing Information) in the future.

Conclusion D - Resource

I look forward to being an informational resource for your practice.

Conclusion E - Meeting

I look forward to our next meeting on [DATE].

Conclusion F - didn't meet

I look forward to reviewing this information with you. In the meantime, you may want to consider whether any patients with certain rheumatic conditions (as specified in the Prescribing Information) in your practice could benefit from a corticosteroid with delayed—release technology.

Please refer to the Important Safety Information provided below.

Signoff A

If you have any questions about RAYOS, please contact me via the email/phone provided below.

Sincerely,

Signoff B

Please don’t hesitate to reach out at any time if you have questions about RAYOS or any other Horizon Pharma product.

Best regards,

Signoff C

Please email or call me with any questions or to schedule a convenient time to meet.

Have a great day!

[Representative Name]

[Email Address]

[Phone]

RAYOS^® (prednisone) delayed—release tablets

INDICATIONS AND USAGE

RAYOS is a corticosteroid indicated:

As an anti-inflammatory or immunosuppressive agent for certain allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, specific infectious diseases or conditions and organ transplantation
For the treatment of certain endocrine conditions
For palliation of certain neoplastic conditions

For a complete list of indications for RAYOS, please see the full Prescribing Information.

IMPORTANT SAFETY INFORMATION ABOUT RAYOS

CONTRAINDICATIONS

Known hypersensitivity to prednisone or any excipients in the formulation

WARNINGS AND PRECAUTIONS

Corticosteroids can cause hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome and hyperglycemia. Monitor patients for these conditions with chronic use. Taper doses gradually for withdrawal after chronic use
RAYOS may increase susceptibility to new infection and increase risk of exacerbation, dissemination or reactivation of latent infection. RAYOS may mask signs and symptoms of infection. The rate of infectious complications increases with increasing doses of corticosteroids
Corticosteroids can cause elevated blood pressure, salt and water retention and hypokalemia. Monitor blood pressure and sodium, potassium serum levels. RAYOS should be used with caution in patients with a history of recent myocardial infarction, congestive heart failure, hypertension or renal insufficiency
There is an increased risk of gastrointestinal (GI) perforation in patients with certain GI disorders. RAYOS may mask signs and symptoms of GI perforation
Corticosteroid use may be associated with behavioral and mood disturbances, including euphoria, insomnia, mood swings, personality changes, severe depression and psychosis. Existing conditions may be aggravated
Corticosteroid use may lead to inhibition of bone growth in children and adolescents and the development of osteoporosis at any age. Give special consideration to patients at increased risk of osteoporosis (eg, postmenopausal women) before initiating corticosteroid therapy, and bone density should be monitored in patients on long-term corticosteroid therapy
Prolonged use of corticosteroids may result in cataracts, infections and glaucoma. Monitor intraocular pressure if corticosteroid therapy is continued for more than 6 weeks
Do not administer live or attenuated vaccines to patients receiving immunosuppressive doses of corticosteroids
Long-term use of corticosteroids can have negative effects on growth and development in children. Monitor pediatric patients on long-term corticosteroid therapy
Fetal harm can occur with first trimester use of corticosteroids. Apprise women of potential harm to the fetus

ADVERSE REACTIONS

Common adverse reactions for corticosteroids include fluid retention, alteration in glucose tolerance, elevation in blood pressure, behavioral and mood changes, increased appetite and weight gain

For a complete list of indications for RAYOS, please see the
full Prescribing Information.

For further information on RAYOS, please see the full Prescribing Information at www.RAYOSRX.com/PI.