Could we be doing more for patients?
 ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌  ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌  ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌
Click here if you are unable to see the message below.
XENLETA™ (lefamulin) 150mg injection | 600mg tablets NOW AVAILABLE
alert icon

Certain patients are at increased risk of
negative outcomes1-3

  • Common comorbidities, such as diabetes and COPD, are significant predictors for hospitalization1-3
rx icon

There are serious safety concerns with
common classes of antibiotics4-6

  • Fluoroquinolones have boxed warnings for adverse side
    effects including tendon rupture, mental health issues, aortic dissections, and hypoglycemia that can lead to coma4-6
hospital icon

Hospitalization may also have negative
consequences7

  • Hospitalization can increase the risk of complications in patients with CABP/pneumonia, including risk of thromboembolic events and "superinfection" by resistant hospital bacteria7
arrow icon

Antibiotic resistance continues to increase8

  • S. pneumoniae causes ~36% of all CABP in adults—but in the last 20 years, it's become increasingly resistant to older classes of antibiotics, such as macrolides, tetracyclines, and penicillins9,10
Choose the different option. Choose XENLETA.
Learn more about an alternative treatment option
References:
1. Liu K, Lee GC. Healthcare utilisation and cost expenditures for pneumonia in individuals with diabetes mellitus in the USA. Epidemiol Infect. 2019;147:1-5.
2. Harding JL, Benoit SR, Gregg EW, et al. Trends in rates of infections requiring hospitalization among adults with versus without diabetes in the U.S., 2000–2015. Diabetes Care. 2020;43:106-116.
3. Ramirez JA, Wiemken TL, Peyrani P, et al; for the University of Louisville Study Group. Adults hospitalized with pneumonia in the United States: incidence, epidemiology, and mortality. Clin Infect Dis. 2017;65:1806-1812.
4. Food and Drug Administration News Release. July 10, 2018. https://www.fda.gov/news-events/press-announcements/fda-updates-warnings-fluoroquinolone-antibiotics-risks-mental-health-and-low-blood-sugar-adverse. Accessed May 14, 2021.
5. Food and Drug Administration In Brief. December 20, 2018. https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-increased-risk-ruptures-or-tears-aorta-blood-vessel/fluoroquinolone-antibiotics. Accessed May 14, 2021.
6. FDA Drug Safety Communication. July 26, 2016. https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-updates-warnings-oral-and-injectable-fluoroquinolone-antibiotics. Accessed May 26, 2021.
7. Mandell LA, Wunderink RG, Anzeuto A, et al. Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44(Suppl 2):S27-S72.
8. Review on Antimicrobial Resistance. Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. Publication of a commission of the UK Government and the Wellcome Trust; O’Neill J, chairperson. https://amr-review.org/sites/default/files/
160525_Final%20paper_with%20cover.pdf. Accessed May 24, 2021.
9. Hamborsky J, Kroger A, Wolfe C, eds. Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th ed. https://www.cdc.gov/vaccines/pubs/pinkbook/index.html. Accessed May 21, 2021.
10. Hicks LA, Chien YW, Taylor TH, et al; for the Active Bacterial Core Surveillance (ABCs) team. Outpatient antibiotic prescribing and nonsusceptible Streptococcus pneumoniae in the United States, 1996–2003. Clin Infect Dis. 2011;53(7):631-639.
Unsubscribe
Nabriva Therapeutics logo All trademarks are the property of Nabriva Therapeutics Ireland DAC
Distributed by Nabriva Therapeutics US, Inc.
© 2021 Nabriva Therapeutics US, Inc.
PM-US-LEF-0334 JUN 2021